Abstract:
This study focuses on the development of an exosome delivery system, called Exo-ITC, with specific applications in dermatology. Exosomes are extracellular vesicles that play a crucial role in intercellular communication and hold great therapeutic potential in regenerative medicine and dermatology. The primary objective of this research is to synthesize a bilayer fibrous system capable of loading and releasing exosomes in a controlled manner for skin applications and collagen production. To achieve this, the system is synthesized using electrospinning techniques, incorporating exosomes into the bilayer fibrous structure. Subsequently, the resulting system is characterized by evaluating its morphology (via scanning electron microscopy), particle size (using dynamic light scattering), stability (through thermogravimetric analysis), and exosome release capacity. The results provide essential insights into the viability and effectiveness of the Exo-ITC system for dermatological applications. It is anticipated that this system could be employed to treat various skin conditions, leveraging the regenerative and therapeutic properties of exosomes. In summary, this thesis represents a significant advancement in the development of innovative topical therapies for skin care.
Biography:
Dr. Luis Villarreal is a research professor at the Faculty of Engineering Sciences and Technology, Autonomous University of Baja California, Tijuana, Baja California, Mexico, member of the National System of Researchers SNII-CONAHCyT Level 2, and a member of the academic body Applied Bioengineering "In Consolidation". To date, Dr. Villarreal has published 51 indexed articles, with a total of 1,134 citations in Scopus. Currently, Research and Graduate Coordinator of the Faculty, General Coordinator of MyDAUD-Multicampus. He has participated in more than 70 national and international conferences. Founder and Editor-in-Chief of the Revista de Ciencias Tecnológicas (RECIT) (only 5 official ones at UABC), organizing president of the main international conferences of the Faculty FCITEC and member of the editorial committee of important publishers such as Bentham, MDPI, Hindawi, Wiley. He is a member of the editorial advisory board of the journal “Current Drug Delivery” and a referee for more than 210 articles participating in publishers such as Elsevier, Wiley, Springer, MDPI and Hindawi among others. He also participates as an evaluator of research projects for funding in Mexico, Italy, Malaysia and Peru. He has contributed to the generation of human resources with 10 undergraduate theses, 10 master's theses and 5 doctoral theses. His research lines in the area of ​​Biomaterials are in Tissue Engineering, Drug Release Systems and Biotechnology, among others. The improvement in the treatment of infants is his primary objective.
