Title: Development and characterization of exo-ITC: A fibrous bilayer exosome delivery system for dermatological applications
Abstract:
This study focuses on the development of an exosome delivery system, called Exo-ITC, with specific applications in dermatology. Exosomes are extracellular vesicles that play a crucial role in intercellular communication and hold great therapeutic potential in regenerative medicine and dermatology. The primary objective of this research is to synthesize a bilayer fibrous system capable of loading and releasing exosomes in a controlled manner for skin applications and collagen production. To achieve this, the system is synthesized using electrospinning techniques, incorporating exosomes into the bilayer fibrous structure. Subsequently, the resulting system is characterized by evaluating its morphology (via scanning electron microscopy), particle size (using dynamic light scattering), stability (through thermogravimetric analysis), and exosome release capacity. The results provide essential insights into the viability and effectiveness of the Exo-ITC system for dermatological applications. It is anticipated that this system could be employed to treat various skin conditions, leveraging the regenerative and therapeutic properties of exosomes. In summary, this thesis represents a significant advancement in the development of innovative topical therapies for skin care.
