Title: Nanoparticle based targeted drug delivery systems for cancer therapy
Abstract:
Cancer is a major reason of death worldwide in human beings and traditional chemotherapy is usually connected with poor specificity, systemic toxicity and unwanted side effects. Nanoparticles based targeted drug delivery systems have come out as a favourable approach to overcome these drawbacks by providing selective delivery of therapeutic agents to the tumour tissues with minimal damage to healthy cells. Various nanocarriers such as liposomes, polymeric nanoparticles, dendrimers and lipid based nanoparticles have shown important possibilities for improving drug bioavailability, enhancing pharmacokinetic profiles and achievingcontrolled drugrelease.Recent advancementsinsurfacemodification and ligandmediated targetinghavefurther improved the specificity and effectiveness of nanoparticle-based therapies. These systems take advantage of the passive targeting by the enhanced permeability and retention (EPR) effect as well as the active targeting by specific molecular interactions with the receptors on the cancer cells. Moreover, nanotechnology has facilitated the codelivery of different therapeutic agents, which has led to synergistic anticancer effects and reduced drug resistance. However, despite remarkable progress, long-term safety, large-scale manufacturing, regulatory approval, and clinical translation remain a major obstacle for generalapplication. Inthisreview, we discussrecent advancesin nanoparticle based targeted drugdelivery forcancer therapy, its therapeutic benefits and limitations, and future prospects of nanomedicine in precision oncology. The ongoing advances in nanotechnology are predicted to transform cancer therapy by enhancing therapeutic results, minimising adverse effects, and facilitatingpersonalisedtreatment strategies.
Keywords: Nanoparticles, Cancer, Drug Delivery, Enhanc Edpermiability and Retention (EPR), Liposomes.
