HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

3rd Edition of Euro-Global Conference on Biotechnology and Bioengineering

June 14-15 | Hybrid Event

June 14-15, 2023 | Rome, Italy
ECBB 2022

Shyamapada Mandal

Shyamapada Mandal, Speaker at Biotechnology Congress
Department of Zoology, University of Gour Banga, India
Title: In Silico Studies Support the Anti-Scrub Typhus Activity of the Bioactive Phytocompounds Andrographolide and Withanolide D

Abstract:

An obligate intracellular bacterium Orientia tsutsugamushi is the causative agent of a febrile disease, scrub typhus, which is endemic to Southeast Asia, including India, wherein there is a recent report on increased emergence of the disease in West Bengal state. The antibiotic treatment failure of scrub typhus prompted us to search for non-antibiotic plant-based therapeutics. Herein we have performed in silico molecular docking of two bioactive phytochemicals, andrographolide (from Andrographis paniculate; Family: Acanthaceae) and withanolide D (from Withania somnifera; Family: Solanaceae) along with a standard treatment, tetracycline against OtDUB (Orientia tsutsugamushi deubiquitylase) protein associated with Orientia tsutsugamushi infection and pathogenesis of scrub typhus. The compound withanolide D (binding energy: -10.2 kcal/mole) had higher affinity to OtDUB compared to tetracycline (binding energy: -9.1 kcal/mole) and andrographolide (binding energy: -8.4 kcal/mole). Both the phytocompounds, andrographolide and withanolide D obeyed Lipinski’s rule of without any violation, and both exhibited high GI absorption and no BBB permeation. The current study results signify the effectiveness and importance of the phytocompounds as non-antibiotic therapy for scrub typhus.

Biography:

Shyamapada Mandal is Professor and Head of the Department of Zoology, and Dean (Science), University of Gour Banga, India. He is interested on infectious diseases, probiotics, and genomics and bioinformatics research. He did pre-PhD, PhD, and post-PhD research under the guidance of Professor Nishith Kumar Pal at Calcutta School of Tropical Medicine, India. He has published 118 articles with eight book chapters. He is life member of IAMM and IASR, India, and fellow member of SASS, India. Eight national academic and research awards have been conferred to him. He has guided 52 post graduate students; supervised three MPhil and three PhD students, and supervising 7 PhD and one MPhil students. Professor Mandal is among the world’s top 2% scientists as per the survey of the Stanford University, published in PLOS (Public Library of Science) Biology (October, 2020). He is featured in the top 2% world scientists list for second consecutive time as published by the Stanford University-Elsevier BV (October, 2021). 

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