Biofilm infections have no approved effective medical treatments and can only be disrupted via physical means. In this work, we describe a hybrid in silico laboratory pipeline for identifying and validating small-molecule inhibitors of RelA for use in the combinatorial treatment of bacterial biofilms as re-potentiators of classical antibiotics.
Dr. Hai-Feng (Frank) Ji is current a professor of Department of Chemistry, Drexel university. His research interests focus on drug discovery, MEMS devices, nanomaterials for energy and environmental applications, nanopillars and phosphene for energy applications, and surface chemistry. He is currently a co-author of 180 peer-viewed journal articles and book chapters. He has an H-index of more than 39.