Title: Biotech scale-up: Bioengineering imperatives in biomanufacturing
Abstract:
During the recent pandemic, it became clear that the main deterrence of manufacturing of newly discovered vaccines was the implementation of prerequisite bioreactor design, operation and control for commercial production. The range of imperatives for success can be wide and complicated in relevant industrial practice. In laboratory experiments, we have encountered concerns of oxygen mass transfer limitations, instability of genetically-engineered microbial hosts for fermentation processes, and rheological irregularities in bioreactor media. Our examples here include wave-induced aeration bioreactor design, reference to regular mechanical stirred-tank and air-lift fermenters, Crispr-based microbial host delivery pattern derivatives, and energy processing requirements. Relevance of geopolitics in biotechnology innovations are observed in the global eco-systems.
Keywords: bioprocess engineering; fermentation process aeration; bioreactor design, operation, control; fermentation kinetics-relevance; biomanufacturing bottlenecks; biotechnology geopolitical interferences; multidisciplinary nature of biotechnology; employment constraints in biomanufacturing.
