Alternative splicing is known to occur in more than 94% if genes in humans. Cancers express specific splice isoforms, or the normal ratios of isoforms are disrupted. While some of these events may be just a silent by-product of the cancer progression, many of them have functional [....] » Read More
Consider the problem of assessing the success of a treatment A and treatment B in cancer patients. The response variable is Y, the patient’s survival in days, and the clinicopathological variables are age, sex, gene expression, and so on. Such data is often censored, meanin [....] » Read More
Sexing by gene editing in pigs is an alluring alternative to the surgical castration of piglets as the male-specific boar taint remains a major obstacle in pork production. In mice, the SRY-gene was first described as a genetic developmental switch for the male phenotype. Th [....] » Read More
Amid the evolving landscape of the BioTech industry, key trends are shaping its trajectory. The interplay of AI, data science and biotech is reshaping diagnostics, drug discovery and personalized medication, offering data-driven insights and transformative solutions. With enhance [....] » Read More
Today, more and more attempts are being made to apply the circular economy model, to overcome the linear economy model, also favouring green and ecological industrial and chemical processes. As a result, molecules from the plant world are becoming increasingly relevant and attemp [....] » Read More
The most important problem in the gene therapy is gene delivery. Cell-penetrating peptides (CPPs) have emerged as versatile tools for delivering various cargoes into cells. However, the exact mechanism of cellular uptake by CPPs remains elusive. This study aimed to explore the ef [....] » Read More
Photoalignment and photopatterning has been deproposed and studied for a long time [1]. Light is responsible for the delivery of energy as well as phase and polarization information to materials systems. It was shown that photoalignment liquid crystals by azodye nanolayers could [....] » Read More
Remodeling eubiosis of the gut microenvironment may contribute to preventing the occurrence and development of depression. Mounting experimental evidence has shown that complement C3 signaling is associated with the pathogenesis of depression, and disruption of the gut microbiota [....] » Read More
Outcomes of anticancer therapy vary dramatically among patients, which may be caused by the specific molecular alterations in each patient’s tumor. The development of ex vivo drug test-guided clinical response prediction platform has elicited clinical and industrial interes [....] » Read More
Introduction: HBV infection is the tenth leading cause of death worldwide, accounting for between 580,000 and 1.2 million deaths per year and approximately 8% of all HBV carriers worldwide are co-infected with the virus hepatitis delta (HDV). In Africa, about a quarter of the 68 [....] » Read More
My paper endeavours to delve into the pertinent influences of biotechnology that can be used toescalate bio conservation practices. Biotechnology can be used to tackle environmental issues like deforestation and air pollution. Biotechnology can help in finding out the level of Pa [....] » Read More
Hydrogen is the most essential gas that can be used for many purposes. During the production of hydrogen using raw materials like Soil and leftover cooked rice water (kanjivellam) the major by-product formed is water. Soil is collected from three different places in kottayam dist [....] » Read More
The exploitation of Manganese in Moanda in the South-East of Gabon leads to the discharge of mining residues into the soil (Mokéa-Niaty, 2019) . The market gardening activities that are developing there expose the populations to the risks of the transfer of metal pollutant [....] » Read More
Background and Purpose: Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma arising from the epithelial lining of the nasopharynx. Inflammation has significant effects on the prognosis of NPC patients. The inflammatory reaction stimulated by cancer is beneficial to its g [....] » Read More
Traditional wound dressings historically served to clean, shield, and safeguard wounds from external factors. However, the right dressing choice can expedite healing, provide cost-effective care, and enhance a patient's well-being. Electrospun fibers, renowned for their varie [....] » Read More
Mycoremediation has become an important approach for managing heavy metal pollution. Cadmium (Cd) is a well-known global contaminant, listed among the most hazardous inorganic substances, but there are few reports about its remediation by mangrove fungi, the highly potential [....] » Read More
Antithrombin III is an important anticoagulant factor with anti-inflammatory properties. However, few studies have explored its anti-inflammatory actions in ATIII overexpressed transgenic animals. In this study, the dairy goats with mammary overexpression of ATIII were used to in [....] » Read More
No one has scientifically proven that antipyretic therapy, which reduces the heat of a fever, is an appropriate treatment for fever and inflammation. Conflicting opinions on the effectiveness of various antipyretic treatments can be found in various journals. Here we consider the [....] » Read More
Subject description: Faidherbia albida is a species that loses its leaves during the rainy season, unlike other savannah plants Objective: The aim of this study was to assess phytohormone levels in the plant's aerial organs during the hot, humid period Method: Phenologi [....] » Read More
Cancer is undoubtedly one of the most prevalent and lethal diseases in this day and age. So, early diagnosis and treatment of this disease are of paramount importance, drawing the attention of researchers and scientists worldwide. Among various methods of diagnosis, Raman spectro [....] » Read More
Zebrafish larva is a simple model system to study blood vessel development because of its excellent optical properties. Current methods to study blood vessels in zebrafish involve utilizing either blood vessel-specific transgenic lines or specialized techniques such as microangio [....] » Read More
Research into alternate ethanol production pathways has been spurred by the need for sustainable energy sources, and lignocellulosic biomass has emerged as a viable feedstock. An integrated method that includes pre-treatment, fermentation, distillation, and enzymatic hydrolysis i [....] » Read More
The presence of medicinal plants is controlled by time and seasons, which requires their conservation, in order to expand their use during the year, as well as their storage and marketing. Our main objective is to study the effect of some conservation methods on garlic, which is [....] » Read More
The orange-yellow essential oil with a yield of 1.54 % was extracted from the dry leaves of Cymbopogon citratus (DC.) Stapf harvested south of Brazzaville. Analysis by gas chromatography (GPC) and gas chromatography coupled with mass spectrometry (GPC/MS) allowed the identificati [....] » Read More
Animal testing has become essential for preclinical screening in the drug discovery process, but there are still several problems, including ethical concerns and species disparities. The use of grown cells for testing drugs' effects and cytotoxicity has become commonplace as [....] » Read More
The mitochondrial disease often associated with various illnesses in relation to the activity of cells metabolites and the synthesis of adenosine triphosphate (ATP). Leigh syndrome part of a continuum of progressive neurodegenerative disorders caused by abnormalities of mitochond [....] » Read More
Important Alert:
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Title : Molecular therapeutics for chronic obstructive pulmonary disease
Yong Xiao Wang, Albany Medical College, United States
Chronic obstructive pulmonary disease (COPD) is a devastating common lung disease. It is the third leading cause of mortality in the world and will be the second leading cause of death by 2020. The current challenging tasks are that the molecular mechanisms for COPD remain largel [....] » Read More
Title : Biotech scale-up: Bioengineering imperatives in biomanufacturing
Murray Moo Young, University of Waterloo, Canada
During the recent pandemic, it became clear that the main deterrence of manufacturing of newly discovered vaccines was the implementation of prerequisite bioreactor design, operation and control for commercial production. The range of imperatives for success can be wide and compl [....] » Read More
Title : A real BandAId™: Incorporating Artificial Intelligence (AI) into biomaterials and medicine
Thomas J Webster, Hebei University of Technology, China
Artificial intelligence (AI) has already revolutionized numerous industries, yet, its use in nanotechnology and biomaterials is almost non-existent. This invited presentation will provide a summary of how AI can be used to design better biomaterials for various biomedical applica [....] » Read More
Title : Pressure plate analysis in musculoskeletal injuries: An overview
Babak Faramarzi, Western University of Health Sciences, United States
Musculoskeletal injuries are extremely common in both humans and Animals. The prevalence of musculoskeletal injuries has increased due to a number of variables, such as decreasing physical activity, higher life expectancy, and professional athleticism. Joint deterioration is a fr [....] » Read More
Title : Experimental measurement of three-dimensional responses of marine mussel plaques anchoring to wet substrates under directional tensions
Yingwei Hou, Queen Mary University of London, United Kingdom
The adhesive structures of marine mussel plaques have attracted significant attention owing to their remarkable adhesive properties. In this paper, we experimentally investigated the three-dimensional (3D) responses of marine mussel plaques anchoring to wet polydimethylsiloxane ( [....] » Read More
Title : Immunogenicity of therapeutic antibodies: Role of aggregation in T lymphocyte response
Isabelle Turbica, Paris Saclay University, France
Immunogenicity has been described as a major concern to the clinical use of therapeutic antibodies, as treated patients frequently develop anti-drug antibodies (ADA) with potential neutralizing capacities leading to loss of clinical response. Among other factors, it is now well a [....] » Read More
Title : Efficient Production of cordycepin, adenosine analog, by Cordyceps militaris mutant
Akihiko Sakurai, University of Fukui, Japan
Cordyceps spp., a mushroom species that parasitizes and grows on insects, has long been used as a herbal medicine. One of its active ingredients, cordycepin, is an analog of adenosine. It is a promising raw material for pharmaceuticals and cosmetics due to its known biological ac [....] » Read More
Title : Process planning optimization of holes drilling using genetic algorithm
Danijela Pezer, University Department of Professional Studies, Croatia (Hrvatska)
The production efficiency has an important role for each manufacturing process, especially in the process of drilling a large number of holes, where production depends on the time required for drilling. The tool path optimization during the drilling is necessary because it leads [....] » Read More
Title : Ursodeoxycholic acid is associated with better clinical outcome in COVID - 19 patients: A population based cohort study
Jong Seung Kim, Jeonbuk National University Medical School, Korea, Republic of
Background: Several studies have investigated the relationship between ursodeoxycholic acid (UDCA) and coronavirus disease 2019 (COVID-19). However, complex and conflicting results have caused confusion in the application of these results. We aimed to investigate whether the asso [....] » Read More
Title : Kertics – Protein bioplastic films from human hair
Shubha Anand, Dayalbagh Educational Institute, India
Conventional plastics have improved humanity in many ways since they were invented, but there is no denying that they have an adverse impact on living things and natural environments. The search for plastic substitutes, or bioplastics, is essential since the management of plastic [....] » Read More
Title : Exploration of nanoformulated phytocompound against fibrogenic mineral dust-induced pneumoconiosis
Sanvidhan G Suke, Priyadarshini College of Engineering, India
Nanoparticular drug delivery is widely studied system to transport a broad range of synthetic drugs, bio-molecules, and natural compounds into the body. However, constant intake of the occupational dose of mineral-rich dust is dangerous, often leading to one of the diseases such [....] » Read More
Title : Electrophoretic deposition of fish bone collagen coupled boron nitride on Ti-6A1-4V for osteointegration
Arjama Mukherjee, Indian Association for the Cultivation of Science (IACS), India
The placement of Titanium implants has become an attractive method for the bone regeneration process. However, the poor osteointegration effects lead to poor cellularization which opens the gateway for novel biocompatible coating. Using these findings here in this work we have pr [....] » Read More
Title : Pretilachlor-induced physiological, biochemical and morphological changes in indian paddy field agroecosystem inhabited anabaena doliolum
Neelam Atri, Banaras Hindu University, India
Pretilachlor is a systemic, pre-emergence herbicide applied in the paddy fields to kill narrow and broadleaf weeds. The present study evaluates the toxicity of pretilachlor on the non-target diazotrophic free-living cyanobacterium Anabaena doliolum, commonly found in the paddy fi [....] » Read More
Title : Implementation of microfluidic phase separation methods and supramolecular host-guest interactions for rapid detection of allergies
Parth Shinde, Tvashtr Biotech Private Limited, India
Microfluidic Phase separation exploits the manipulation of fluid flow and the interaction of different phases to isolate and concentrate the target analytes from complex biological samples. In this paper, we review the recent progress in phase separation microfluidics for allergy [....] » Read More
Title : The prospects of algae in the development of bioplastics: A review
Manaswi Rani, Dayalbagh Educational Institute, India
Plastic has detrimental effects on environment, animal, and human health, due to its non-biodegradable nature. Bioplastic, an environment friendly material, can be derived from biologically renewable resources. Research is now focused on developing biodegradable bioplastic due to [....] » Read More
Title : The scale-up and culturability of live biotherapeutics for reproductive health in South Africa
Obakeng Jona, University of Cape Town, South Africa
Bacterial vaginosis is a highly prevalent inflammatory condition, characterised by the absence of protective. Lactobacillaceae commensal species and their replacement by vaginal pathogens such as Gardnerella vaginalis. It is known to increase HIV infection rates and thus presents [....] » Read More
Title : Valorization of tropical biofood resources to combat anaemia and vitamin A deficiency
Djuikwo Ruth Viviane, University of Yaounde 1, Cameroon
Anaemia and vitamin A deficiency in children and pregnant women are a public health problem in Cameroon. The Cameroon government, with the support of the WHO and UNICEF, is helping to combat these deficiencies by giving vitamin A supplements to children and pregnant and breastfee [....] » Read More
Title : Impact of abiotic stress on performance of Nepalese Wheat (Triticum aestivum L.) genotypes and molecular characterization by using stress linked SSR marker
Mukti Ram Poudel, Tribhuwan University, Nepal
Abiotic stresses are the major yield limiting factors for wheat production worldwide. Identification of stable and high yielding genotypes of wheat could be done using additive main effects multiplicative interaction (AMMI) and genotype×genotype×environment biplot (GG [....] » Read More
Title : Improving texture of bacterial cellulose produced by Komagataeibacter xylinus PTCC 1734 by optimization of fermentation parameters
Javad Hamedi, University of Tehran, Iran (Islamic Republic of)
Bacterial cellulose (BC) is a biodegradable and non-toxic polymer that has various applications in various industries, including food industry. Due to having a structure with many pores and a dense network of microfibrils, this biopolymer has a high ability to combine with differ [....] » Read More
Title : Effect of human umbilical cord matrix stem cell conditioned media in cuprizone mice model of multiple sclerosis
Mohsen Marzban, Iranshahr University of Medical Science, Iran (Islamic Republic of)
Introduction: Human Umbilical Cord Matrix Stem Cells (h-UCMSCs) elicit neuroprotective effects, and their repair ability has been investigated in different experimental models. We aimed to investigate the effect of h-UCMSCs supernatant or conditioned media in the cuprizone mice m [....] » Read More
Title : Production of nanoliposomal amphotercin B topical gel as effective treatment for human Cutaneous Leishmaniasis (CL) disease
Abdulsada A Rahi, Wasit University College of Science, Iraq
Human cutaneous leishmaniasis (CL) is the disease caused by Leishmania sp. parasite and it endemic in Iraq and other world countries. This study comprised 78 cases of suspected CL disease. Before treatment, 66 (84.6%) cases were positive and 12 (15.4%) cases were negative among t [....] » Read More
Title : Bioadhesive microneedle patches for tissue sealing
Neta Shimony, Technion, Israel
Sealing of soft tissues prevents leakage of gas and liquid, closes wounds, and promotes healing and is, therefore, of great significance in the clinical and medical fields. Although various formulations have been developed for reliable sealing of soft tissue, tradeoffs between ad [....] » Read More
Title : Indoor biomass fuel as a higher risk factor for TB in HIV positive female patients of Western India
Rajeev Shah, Kiran Medical College, India
Backgroud:-It is well known that one third poor population of world use biomass fuel for cooking and heating. It is universally accepted fact that bio-mass fuel plays a significant role as predisposing factor of tuberculosis, acute respiratory tract infections and COPD even in no [....] » Read More
Title : Genetically modified mosquitoes using CRISPR-Cas9 gene editing technology to inhibit the transmission of the malaria parasite
Miranda Elorm Fiavi, Al Akhawayn University in Ifrane, Morocco
About a quarter billion people are infected with malaria each year, with most cases occurring in sub-Saharan Africa, with a mortality rate of more than 600,000 humans per year. One of the main problems is the superior capacity of the mosquito vectors Anopheles gambiae to acquire [....] » Read More
Title : Invitro regenration of Echinops kebericho from shoot explants
Habtamu, Ethioparents School, Ethiopia
Echinops kebericho is an erect massive rootstock bearing perennial herbs or shrub belonging to the family Asteraceae. Echinops kebericho, endemic to Ethiopia is a critically endangered medicinal plant. It is among few important medicinal plants of the country valued primarily for [....] » Read More
Title : Effect of eggplant/basil association on the major pests of eggplant under Sudan-Sahelian conditions in Mali
Bibata Ali Outan, National Institute of Agronomic Research of Niger (INRAN), Niger
Eggplant is one of Mali's most widely grown and pest-ridden vegetables. Whitefly (Bemisia tabaci), leafhoppers (Ampoasca spp) and aphids (Aphis gossypii) have a negative impact on production. To minimize the resulting losses, the biological efficacy of basil (Ocimum basilicum [....] » Read More
Title : Morphological, biochemical, and molecular characterization of exotic brassica germplasm
Fawad Ali, Bacha Khan University Charsadda, Pakistan
Oilseed rape (Brassica napus L.) is an important oilseed crop. We examined the diversity of germplasm expressed at three distinct levels (i.e., morphological, biochemical, and DNA levels). For this study, the Bio resources Conservation Institute provided 150 B. napus L. accession [....] » Read More
Title : Molecular epidemiology of Hepatitis B virus (HBV) genotypes prevalent in KP
Farzana Na, Women University Mardan, Pakistan
Hepatitis B virus (HBV) infection is a major public health dilemma affecting about 2 billion of world population and more than 350 million people are chronically HBV carriers including Pakistan with an estimated prevalence rate of 3%. HBV can be categorized into 10 genotypes (A-H [....] » Read More
Title : Pectinase immobilization in agarose: Efficiency, stability, and kinetic modifications
Haneef Ur Rehman, University of Turbat, Pakistan
Pectinase from Bacillus species was immobilized in an agarose matrix using the entrapment technique. The impact of varying agarose concentrations on pectinase immobilization was studied, revealing that the highest immobilization efficiency was achieved with 1.0% agarose, maintain [....] » Read More
Title : Mapping neural contributions of GLP-1 receptor agonism to phenotype using machine learning
Isabelle Sajonia, University of Virginia, United States
GLP-1, an incretin hormone, targets the G protein-coupled receptor GLP-1R, expressed in brain regions crucial for regulating food intake and satiety, particularly in the hypothalamus. Recently, two long-acting peptide GLP-1R agonists (GLP1RAs), liraglutide and semaglutide, were a [....] » Read More
Title : Valorization of wastes via a one-step microbial fermentation process
Fernando Santos Beneit, University of Valladolid, Spain
Pollution from plastic waste represents one of the most relevant environmental problems that our society currently faces. Most conventional plastics are extremely recalcitrant, with estimated decomposition times of decades to centuries. However, the production of plastics increas [....] » Read More
Title : Production of hydroxyectoine with an engineered strain of Methylomicrobium alcaliphilum
Sergio Bordel, University of Valladolid, Spain
Methylomicrobium alcaliphilum is a halotolerant methanotroph, which produces ectoine under high salinity conditions. Ectoine is an osmoprotector and protein stabilizer that allows microorganisms to survive at high salt concentrations (up to 9% in the case of M. alcaliphilum) and [....] » Read More
Title : Water biosense? , an innovative technology for real-time monitoring of biological agents and biomarkers of health and environmental interest in water
Ivan Iglesias Baena, Sensactive Technology S.L., Spain
Drought is an increasingly frequent phenomenon with significant impacts on the economy, quality of life, and the environment. According to the World Health Organization, more than 2 billion people suffer water scarcity, a situation exacerbated by climate change and population gro [....] » Read More
Title : Nano gold-enhanced bioglass: Unveiling in vitro and in vivo bioactivity characteristics for advanced medical applications
Yousef Alobaisi, King Fahad Medical City, Saudi Arabia
Incorporated gold ions Au into glass with composition 30P2O5-20Ca(OH)2-20ZnO8.0KF-5B2O3-2.0TiO2 in mol% with 400ppm (Gold III Chloride trihydrate HAuCl4-3H2O) and 600ppm (Gold III Chloride trihydrate HAuCl4-3H2O) by using terdiurnal method quenching method. The present glass' [....] » Read More
Title : The evolution of reproductive mode in the Carassius auratus complex
Reem Alhaidose, Ministry Of Municipality - Biotech Center, Qatar
Freshwater fish of the genus Carassius are widely spread in Asia, Europe, and Australia. This includes the Carassius auratus complex, a phylogenetically diverse species complex with uncertain taxonomy. The C. auratus complex is native to Asia but has been introduced to non-native [....] » Read More
Title : Cloning and characterization of a vasa homolog in the giant grouper (Epinephelus lanceolatus) and its specifically expression in gonad
Surintorn Boonanuntanasarn, Suranaree University of Technology, Thailand
The vasa gene has been the most used as a gene marker for germ cell in vertebrate; particularly in fish. This study cloned and characterized a vasa homolog in the giant grouper (Epinephelus lanceolatus) and designated as Elvasa. Our result showed that Elvasa contained predicted r [....] » Read More
Title : Expression of Tc-MypPA gene involved in the regulation of the biosynthesis of proanthocyanidins in some cocoa beans (Theobroma cacao L.)
Manga Ndjaga Jude, University of Yaounde I, Cameroon
Proanthocyanidins (PAs) are known as flavor precursors of a chocolate. In the course postharvest processes (fermentation and drying), PAs impart astringency and bitterness to many cocoa bean genotypes. The goal of this work was therefore to see if there was a relationship between [....] » Read More