Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) represent a revolutionary technology in the field of genetic engineering and molecular biology. Originally discovered as a bacterial immune system, CRISPR has been repurposed as a powerful tool for precise genome editing in various organisms. The CRISPR system consists of two main components: guide RNA (gRNA) and the Cas9 protein. The gRNA guides the Cas9 protein to specific target sequences in the genome, where it induces double-strand breaks. These breaks can be repaired by the cell's own DNA repair machinery, leading to gene knockout, insertion, or modification. The simplicity, versatility, and efficiency of the CRISPR system have made it widely adopted in research laboratories worldwide. CRISPR technology has revolutionized gene editing, enabling researchers to edit genomes with unprecedented precision and ease. It has facilitated the study of gene function, disease modeling, and the development of novel therapies for genetic disorders. Additionally, CRISPR has applications beyond gene editing, including gene regulation, epigenome editing, and diagnostic tools. Despite its tremendous potential, CRISPR technology also raises ethical and societal concerns, particularly regarding off-target effects, germline editing, and the potential for unintended consequences. Ongoing research aims to address these challenges and refine the CRISPR system for safe and effective use in various applications.
Title : Biotech innovations: Bioengineering potential for novel biomanufacturing systems
Murray Moo Young, University of Waterloo, Canada
Title : Targeting noncanonical epitopes in anti-cancer immunotherapy
Michele Mishto, Francis Crick Institute, United Kingdom
Title : Eliminating implant infection: 30,000 nanotextured implants in humans with no failure
Thomas J Webster, Interstellar Therapeutics, United States
Title : Stem cell therapy: An affordable healthcare therapy for various diseases
Anant Marathe, Total Potential Cells (P) Ltd, India
Title : Information leakage: Types, remedies, and open problems
Julia Sidorova, Centro de Investigación Biomédica En Red Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain
Title : Development and characterization of exo-ITC: A fibrous bilayer exosome delivery system for dermatological applications
Luis Jesus Villarreal Gomez, Universidad Autonoma de Baja California, Mexico