The healthcare and pharmaceutical industries need ever more performing, safe and economical solutions for both diagnostic and therapeutic applications including anti-inflammatory, antioxidant and antitumor remedies, but also nutraceutical and cosmeceutical preparations. Since man [....] » Read More
Nanotechnology is now a mature field in numerous industries from energy to building constructs to medicine. Nanomaterials have specifically revolutionized how we prevent, diagnose, and treat diseases. In this presentation, a review of the use of nanomaterials in humans will be pr [....] » Read More
Biosurfactants are amphipathic molecules that can be applied in a wide range of areas. These compounds can be widely used in industries as pharmaceutical agents, and for microbial-enhanced oil recovery, among others. Amongst these biosurfactants, surfactin, rhamnolipids, and mann [....] » Read More
Wound dressings have been used to clean, cover, and protect the wound from the external environment. However, choosing an adequate dressing will reduce the time of healing, provide cost-effective care, and improve the patient’s quality of life. Electrospun fibers have gaine [....] » Read More
Researchers in the field of cell and gene therapy have long faced the daunting task of efficiently and extensively expanding cells. Overcoming the limitations of the 2D planar culturing system has been a significant challenge. However, we have made a groundbreaking advancement by [....] » Read More
Plant digital genomics is a rapidly growing field that aims to study plant biology through high-throughput techniques such as transcriptomics, genomics, and proteomics. Artificial intelligence (AI) algorithms have emerged as powerful tools to analyze the large datasets generated [....] » Read More
Nature has blessed humans in numerous ways and the tiniest one is ‘microorganisms’ which instead of being so small in size, have served in a huge manner to all. They are well-documented for production of various primary and secondary metabolites which hold outstanding [....] » Read More
Conventional farming techniques help in fulfilling food demand but they are harmful to humans and environmental sustainability. These largely depend on chemical fertilizers that cause food contamination and soil toxicity and deteriorate the physical, chemical, and biological prop [....] » Read More
Over the past decade, development of renewable non-petroleum based sustainable processes for bitumen has attracted attention. Recently, proof of concept was established to transform algae-biomass residues into a material mimicking the rheological behaviour of a bitumen through a [....] » Read More
Nitric Oxide (NO), a signal molecule plays vital role to provide tolerance to abiotic stress in plants by interplay with reactive oxygen species, and thus promoting their growth and development. Arsenic (As) is a toxic metalloid and its contamination found in crop plants, mainly [....] » Read More
Agricultural production of arable crops will necessarily call on the full range of available solutions: choice and rotation of crops, tillage, fertilizers, phytosanitary products, biological control of pests, varietal selection, irrigation...etc. Today, the arable crops sector us [....] » Read More
In this study nitrogen containing TiO2 nanoparticles were doped on GO and TiO2-N-GO Nanocomposite was produced under laboratory conditions to treat the chemical industry wastewater containing high H2S under UV light. 5%- 3%-1%,3%- 5%-1%and 1%- 5%-1%3 ratios [....] » Read More
The expression of a set of genes in a metabolic pathway can be regulated by a single transcription factor (TF). The use of TFs can, therefore, be a promising strategy for generating plants with superior traits. Triticum aestivum Dof1 TF is known to regulate nitrogen assimilation [....] » Read More
Coffee leaf rust (CLR) caused by Hemileia vastatrix is a major disease for coffee-producing countries. Breeding for resistant varieties is the main strategy for controlling CLR, however, the rapid spread of this disease around the globe and ongoing CLR races, are limiting cultiva [....] » Read More
Title : Tailoring composition, bioactivity, and porous structure of 3D-printed scaffolds for tissue engineering
Dario Puppi, University of Pisa, Italy
Advanced regenerative medicine strategies rely on the use of 3D scaffolds with tailored composition and porous structure in order to optimize tissue engineering processes. This contribution aims at overviewing recent research activities carried out in this context and focussed on [....] » Read More
Title : Analysis of molecular features and therapeutic potential of l-asparaginase from a Marine bacterium
Rajesh Pratap Singh, IIT Roorkee, India
L-asparaginase is an antileukemic enzyme that is majorly utilized in the treatment of acute lymphoblastic leukaemia (ALL) and other blood cancers. A number of groups have made efforts to explore this vital agent. However, the use of L-asparaginase has been observed to have severa [....] » Read More
Title : Yabby-mediated transcriptional regulation of artemisinin biosynthesis in Artemisia annua
Sadaf Ilyas Kayani, Jiangsu University, China
Artemisinin is an effective antimalarial sesquiterpene lactone synthesized in Artemisia annua. Artemisinin-based combination therapies (ACTs) are recommended by the World Health Organization (WHO) as the best choice to cure acute malaria. Many transcription factors regulating art [....] » Read More
Title : The lactic acid bacteria lactococcus lactis an surprisingly produce intracellular vesicles
Frelet Barrand Annie, Institute FEMTO, France
Membrane proteins (MPs) perform a wide variety of functions vital to the survival of organisms. Involved in numerous pathologies, they are important drug targets. In spite of their functional and biotechnological importance, their study remains difficult due to their hydrophobici [....] » Read More
Title : Prospects of human hair keratin based biomaterials
Shubha Anand, Dayalbagh Educational Institute, India
Keratin is the major structural fibrous protein providing outer covering such as hair, wool, feathers, nails and horns of mammals, reptiles and birds. Keratin fibers, such as wool and human hair, consist of two major morphological parts: the cuticle layer which is composed of ove [....] » Read More
Title : Nanofiltration mediation for efficient production of second generation bioethanol by wild-type yeast from Lignocellulosic hydrolysate
Gopal Prasad Agarwal, Indian Institute of Technology Delhi, India
Nanofiltration, a relatively new synthetic membrane-based separation process was first used to fractionate lignocellulosic hydrolysate. The fractionated streams of permeate and retentate were fermented separately to produce bioethanol in high yield. The choice of the right nanofi [....] » Read More
Title : Carboxylesterase modification (With lithium) As therapeutic enzyme for human Brain diseases.
Prabha Muddobalaiah, Ramaiah Institute of Technology, India
Carboxylesterases (CEs) are hydrolytic enzymes involved in anticancer drug metabolism. Human WHO grades all meningiomas and gliomas exhibited lower CE-specific activity which proves one of the main reasons for the failure of chemotherapy. The similar CE-specific activity bet [....] » Read More
Title : Structural insight into cellular regulation by human DND1 and associated conformational plasticity
Pooja Kumari, Amity University, India
RNA Recognition Motifs (RRMs) being the most abundant RNA binding domain in eukaryotes, is a major player in cellular regulation. Human DND1 (dead-end protein homolog1) also known as microRNA-mediated repression inhibitor 1 is an RNA-binding protein containing two RRMs in ta [....] » Read More
Title : Study of newcastle disease virus-induced oncolytic effect in MDA-MB231 breast cancer cell line
Upasana Pathak, Vivekanand Education Society's College of Arts, Science & Commerce, Sir H.N. Reliance Foundation Hospital and Research Centre, India
Newcastle disease virus (NDV) exhibits oncolysis in its natural form. This oncolytic virus (OV) has the potential to specifically infect, propagate, and lyse cancer cells while sparing the normal cells. this study screened for oncolytic NDV strain isolated from poultry. The cytop [....] » Read More
Title : Plant Mirna applications and importance against sars-cov-2 genome
Sebnem Kavakli Yildiz, Ege University, Turkey
RNA interference is a post-transcriptional modification of gene silencing mechanism. It presents in a wide range of organisms like plants, fungi, both vertebrates and invertebrates and inside of the most important mammals. As short RNAi mechanism can apply by double-stranded shor [....] » Read More
Title : Preparation and characterization of STING agonists-delivering LNP systems for cancer treatment
Mustafa Kotmakci, Ege University, Turkey
Glioblastoma (GBM) is the most common brain tumour in adults that has poor prognosis and still considered incurable with a very short median survival after diagnosis. The stimulator of interferon genes (STING) in conjunction with cyclic GMP-AMP synthase (cGAMP) is a cytosolic DNA [....] » Read More
Title : Influence of proteins extracted from tarantula spider silk on the survival of mesenchymal stem cells
Dauddin Daudi, ITMO, Russian Federation
The skin is the largest organ in the human body. The skin's main function is barrier, and it protects internal organs, so it accounts for the greatest amount of damage. Wound healing is a complex process involving the interaction of cells and matrixes with further formation o [....] » Read More
Title : Biotechnological explorations of phyto-drugs against mdr bacterial infections from medicinal plants of West Bengal, India.
Asit Kumar Chakraborty, Vidyasagar University, India
Escherichia coli, Salmonella enterica, Acinetobacter baumannii, Pseudomonas aeguginosa, Enterococcus faecium and Klebsilla pneumoniae etc mediated infections were not cured by conventional antibiotics due to presence of multiple large and small MDR plasmids with >10 mdr (amp, [....] » Read More
Title : Insights into molecular evolution, characterization, and expression analysis of spl Gene family in chickpea (Cicer arietinum)
Shilpy Singh, Noida International University, India
Background: Plant-specific transcription factors (TFs) named SQUAMOSA promoter binding protein-like (SPL) proteins have a number of developmental roles in plants, including growth, flowering, and signal transduction. A gene family that encodes SPL proteins has been identified in [....] » Read More
Title : Detection of ellagic acid at the intracellular level led to the design of mimetic of ellagic acid (MEA) as potential inhibitor of c-Raf and c-Ras
Nilesh Kumar Sharma, Dr. D.Y. Patil Vidyapeeth, India
The side effects of existing drugs and other methods, which are effective in decreasing the progression of cancer, are quite harmful and toxic to our bodies. To tackle this, a safer method needs to be derived. Dietary and their gut metabolized chemicals are being explored for inh [....] » Read More
Title : Coagulation in human immunodeficiency virus infection: A Target for improvement of the patients
Emmanuel Ifeanyi Obeagu, Kampala International University, Uganda
According to UNAIDS, there were approximately 37.9 million people across the globe with HIV/AIDS in 2018. Of these, 36.2 million were adults and 1.7 million were children (< 15 years old). New HIV infection – An estimated 1.7 million individuals worldwide were newly infe [....] » Read More
Title : Comparison of different nanofiber scaffolds effects on bone regeneration of calvaria defect in a Wistar rat model - Importance of porosity
Fanny Gimie, Gip cyroi, France
Skeletal tissue injury is a major burden on the global healthcare system due to an aging population. In addition, metabolic disorders such as diabetes and osteoporosis further impede the healing process. Tissue engineering scaffold for reconstructive strategies offer exciting opp [....] » Read More
Title : Diversity of cadmium repressor genes and their use in whole cell biosensors
Pamela Obando, Universidad Peruana Cayetano Heredia, Peru
Cadmium is a toxic heavy metal that is present as a contaminant in water and soil. Despite this, there are microorganisms that have developed tolerance and resistance to this metal due to their continuous exposure. The most common strategy in microorganisms is to activate the exp [....] » Read More
Title : Sequencing analysis of pyelonephritis-associated pili Gene of uro-pathogenic escherichia coli isolated from iraqi patients from Baghdad
Maysaa Abdul Razzaq Dhahi, Al Nahrain University, Iraq
Pyelonephritis-associated pili (Pap) fimbria considered as the main adhesive virulence factor that enable Escherichia coli(E. coli) to colonize in the urinary tract and resist the avoiding by the flow of urine. DNA adenine methyl-transferase gene (Dam) have a role in regulation o [....] » Read More