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2nd Edition of Euro-Global Conference on Biotechnology and Bioengineering

June 13-14 | Rome, Italy

June 13-14, 2022 | Rome, Italy
ECBB 2022

Alexandra Peregrina Lavin

Alexandra Peregrina Lavin, Speaker at Biotechnology
NOVA University of Lisbon, Portugal
Title: Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis

Abstract:

The large production of non-degradable petrol-based plastics has become a major global issue due to its environmental pollution. Biopolymers produced by microorganisms such as polyhydroxyalkanoates (PHAs) are gaining potential as a sustainable alternative, but the high cost associated with their industrial production has been a limiting factor.

Post-transcriptional regulation is a key step to control gene expression in changing environments and has been reported to play a major role in numerous cellular processes. It involves bacterial small non-coding RNAs (sRNAs) and important enzymes as ribonucleases (RNases), which are versatile and potent regulators. However, limited reports are available concerning the regulation of PHA accumulation in bacteria, and many essential regulatory factors still need to be identified. Some of these studies and a recent review on the topic, have informed that the synthesis of PHAs can be regulated at the post-transcriptional level, and analyze the RNA-mediated networks involved. The absence or truncation of some of those regulating-genes could result in the alteration of the total PHA cellular accumulation. In consequence, it suggests that those riboregulators would be interfering (direct-or indirectly) some PHAs synthesis pathways in very well recognized bacteria for their abilities to synthesize polyhydroxyalkanoates.

Therefore, the discussion of the forthcoming research on riboregulation, synthetic, and metabolic engineering could lead to improved strategies for PHAs synthesis in industrial production, thereby reducing the costs currently associated with this procedure.

Biography:

Dr. Alexandra Peregrina Lavín received her PhD degree from the University of Granada (Spain) in 2017, and during her professional activities joined others research groups, such as the SYNMIKRO LOEWE Center in Marburg (Germany) and the ITQB NOVA Institute (Oeiras, Portugal). She has been co-author of 8 research articles of high impact, based in the areas of Natural Sciences and Engineering & Technology, with emphasis on Microbiology.

In 2018 participated in the EmPowerPutida consortium in the frame of H2020, and in 2019 was awarded with the competitive individual fellowship of the Marie Sklodowska-Curie Actions for the production of bioplastics from microorganisms, as sustainable alternative to petrol-based plastics.

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