Title: Exosome-based strategies for diagnosis and therapy of glioma cancer
Abstract:
Glioblastoma belongs to the most aggressive type of cancer with a low survival rate that is characterized by the ability in forming a highly immunosuppressive tumor microenvironment. Intercellular communication are created via exosomes in the tumor microenvironment through the transport of various biomolecules. They are primarily involved in tumor growth, differentiation, metastasis, and chemotherapy or radiation resistance. Recently several studies have highlighted the critical role of tumor-derived exosomes against immune cells. According to the structural and functional properties, exosomes could be essential instruments to gain a better molecular mechanism for tumor understanding. Additionally, they are qualified as diagnostic/prognostic markers and therapeutic tools for specific targeting of invasive tumor cells such as glioblastomas. Due to the strong dependency of exosome features on the original cells and their developmental status, it is essential to review their critical modulating molecules, clinical relevance to glioma, and associated signaling pathways. This review is a non-clinical study, as the possible role of exosomes and exosomal microRNAs in glioma cancer are reported. In addition, their content to overcome cancer resistance and their potential as diagnostic biomarkers are analyzed
Audience Take Away Notes :
- Considering the increasing prevalence of glioma cancer in the world, it helps to familiarize with the Exosome?based strategies for diagnosis and therapy against it
- Other faculty could use to expand their research or teaching from this research and develop more strategies for diagnosis and therapy of glioma cancer
- It will provide new information to assist in a design of strategies for diagnosis and therapy of glioma cancer
- The rapid development of drug resistance in tumor cells has become the most significant challenge in cancer treatment. Glioma therapy based on the role of exosomes in the initiation and progression of cancer has recently been well stabilized
