HYBRID EVENT: You can participate in person at London, UK or Virtually from your home or work.

5th Edition of Euro-Global Conference on Biotechnology and Bioengineering

September 18-20 | Hybrid Event

September 18-20, 2025 | London, UK
ECBB 2025

Neuroprotective effect of RMF in sporadic parkinson’s disease model mice

Umer Aanayyat, Speaker at Bioengineering Conferences
Shenzhen University, China
Title: Neuroprotective effect of RMF in sporadic parkinson’s disease model mice

Abstract:

Progressive loss of dopaminergic neurons in Substantia Nigra Par Compacta (SNpc) due to aggregation of Lewy bodies is the hallmark of Parkinson’s disease (PD). ROS plays a key role in formation of Lewy bodies, thus leading to mitochondrial dysfunction and apoptosis of neurons. Rotating magnetic field (RMF) is an emerging non-invasive technique for prevention of neurodegenerative disorders. To investigate the potential therapeutic effects of RMS in PD, we subjected an experimental mouse model to RMF. CblC mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (30 mg/kg, i.p., once daily for 5 days) followed by RMF treatment at a frequency and intensity of 4 Hz and 0.4 T respectively. The daily 2 hours treatment with RMF was continued for a period of 6 months. We examined the effect of RMF on motor functions, aggregation of Lewy bodies and the integrity and viability of total and dopaminergic neurons in SNpc and striatal regions. We further performed the transcriptomic analysis of SNpc tissue of PD versus the SHAM mice. Our results showed that exposure to RMF improved the motor functions, enhanced neuronal cell viability and protected their integrity in PD mouse model. We further showed that RMF diminishes the aggregated Lewy bodies in the neurons and reduces ROS production. The whole transcriptomic analysis uncovered that RMF promotes the expression of anti-apoptotic versus the pro-apoptotic genes specifically involved in mitochondrial apoptosis.

Biography:

He is a biomedical researcher with a strong background in molecular biology, immunology, and cancer research, backed by a master’s in biotechnology from NTNU. His experience spans Norway and China, where he worked on cutting-edge projects involving microRNA in lung and cardiac diseases, cancer immunotherapy, and stem cell-based technologies. Currently, he leading a project focused on developing MSC-Light tumor immunotherapy at the National Engineering Research Centre for CGT Industry, combining scientific innovation with strategic project management.

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