Title: Investigation of antibacterial activity and inhibition of biofilm formation of Sterculia lychnophora extract against Staphylococcus aureus and Pseudomonas aeruginosa
Abstract:
The problem of antibiotic resistance is becoming more and more serious, one of the causes is due to the mechanism of biofilm formation that prevents antibiotics from contacting bacteria, and at the same time spreading antibiotic resistance genes in the bacterial population. Scaphium macropodum fruit extract has been shown to have antibacterial activity, extracts from different extraction procedures and fractions will have different antibacterial and inhibitory activities on biofilm formation.Therefore, in this study, I investigated the antibacterial activity and inhibition of biofilm formation of the extracts of the extracts of two types of bacteria Staphylococcus aureus and Pseudomonas aeruginosa. The results showed that at a concentration of 100mg/ml, Scaphium macropodum extract had antibacterial activity against S.aureus with an antibacterial ring diameter of d=16mm but no antibacterial activity against P.aeruginosa. However, the extract has the ability to inhibit biofilm against both types of bacteria. For S.aureus, segments A+B-2, C-3, D-1, C-4-2, C-4-3, CYH-S12 at concentrations 0.0625 mg/ml and CYH-AA6, CYH-N63 at a concentration of 0.125 mg/ml had high membrane inhibitory activity. For P.aeruginosa, segments A+B; A+B-1; C-3; D-3 at a concentration of 0.25 mg/ml had high membrane inhibitory activity.
Audience Take Away Notes:
The audience can better understand the situation of antibiotic resistance and the role of traditional medicine, especially medicinal herbs in the treatment of antibiotic-resistant infections.
