Title: Electrophoretic deposition of fish bone collagen coupled boron nitride on Ti-6A1-4V for osteointegration
Abstract:
The placement of Titanium implants has become an attractive method for the bone regeneration process. However, the poor osteointegration effects lead to poor cellularization which opens the gateway for novel biocompatible coating. Using these findings here in this work we have prepared a novel coating material using hexagonal boron nitride and fishbone collagen. This biocompatible coating can have mechanical strength, antibacterial property, and osteointegration property which can be appropriate for BTE application. Further, the coating of this bioactive aerogel material on a Titanium implant will lead to a successful formation of a smart aerogel implant for bone healing. The preparation and coating of commercially pure titanium samples with collagen-poly(dialdehyde) guar gum conjugated hexagonal boron nitride by electrophoretic deposition for bone tissue engineering applications. The structural characterization, FTIR, XRD, and TGA were used while scanning electron microscopy (SEM) equipped with EDS was done to investigate the morphological characterization. The coating morphology, thickness, and adhesion behavior were studied and proved for developing uniform bioactive coatings of PDAGG-collagen conjugated BN on titanium plate by EPD. Further, this implant leads to an increase in MG-36 fibroblast cell density and proliferation thereby implying its high potential to be used as an implant for bone tissue engineering applications.
Audience Take Away Notes:
- The placement of Titanium implants has become an attractive method for the bone regeneration process. The electrophoretic deposition has become a very interesting option to coat an implant material used for bone tissue engineering which improves the surface property and bioactivity of the implant
- We have prepared a novel coating material using hexagonal boron nitride and fishbone collagen. This biocompatible coating can have mechanical strength, antibacterial property, and osteointegration property which can be appropriate for BTE application
- Our work suggested that the implant is non-toxic, provide good cellularization thereby promising as an effective system for bone tissue engineering applications
